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pentobarbital decreases levels of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Steer clear of unless the coadministration outweighs the feasible risk of ponatinib underexposure; check for signs of reduced efficacy.pentobarbital will lessen the extent or influence of pitolisant by impactin

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